The Molaro Lab – Evolutionary Epigenomics and Genetic Conflicts – is seeking postdoctoral fellows to investigate the functional consequences of epigenome evolutionary diversification in mammals.

ERC-funded position for 3 years

Who we are

Our team studies how genetic conflicts shape the evolution and function of the epigenome. We combine phylogenetic approaches with in vivo epigenome profiling to identify genetic innovations in chromatin pathways and characterize their function (e.g., see Mordier et al., BioRxiv, 2024; Molaro et al., Genome Research, 2018; Mol. Biol. Evol., 2020). We study these questions in normal and pathological contexts, using mouse models and mammalian tissue culture (e.g., see Molaro et al., PLoS Biology, 2020; Chew et al., Nature Comm., 2021).

Proposed project

Through the “EvoEpi” project, postdoctoral fellows will investigate the functions of germline chromatin pathways subject to diversifying selection in primates and rodents. These pathways include histones proteins with novel parental-effects during reproduction, and nucleosome interacting enzymes with currently uncharacterized rapidly evolving functions. Fellows will develop original comparative cross-species epigenome profiling approaches in mouse models or tissue culture. We provide a secured 3-year salary with full benefits. We also provide career development and training programs throughout the contract.

Candidate profile

• Ph.D. in one of the following fields: molecular biology, chromatin biology, genomics or epigenomics.
• Skills recommended in high throughput sequencing, tissue culture and/or mouse genetics.
• Scientific interests: evolution and epigenomics
• The candidate will be encouraged to apply for independent funding

Application details:

• Reviewing applications until August 2025 for a start date as early as possible.
• Please contact Dr. Antoine Molaro – antoine.molaro@uca.fr – with the following:
  • CV
  • Cover letter/e-mail (1 page)
  • Contact details of 2 professional references

The iGReD is an equal opportunity employer, we encourage applications from all backgrounds and genders.