Funders
Members
Publications
Alternative splicing is an FXRα loss-of-function mechanism and impacts energy metabolism in hepatocarcinoma cells.
Published on 26 Nov 2024 in The Journal of biological chemistry - pp 108022
Garcia M , Holota H , De Haze A , Saru JP , Sanchez P , Battistelli E , Thirouard L , Monrose M , Benoit G, Volle DH, Beaudoin C
Constitutive Androstane Receptor Regulates Germ Cell Homeostasis, Sperm Quality, and Male Fertility via Akt-Foxo1 Pathway.
Published on 24 Sep 2024 in Advanced science (Weinheim, Baden-Wurttemberg, Germany) - pp e2402082
Monrose M , Holota H , Martinez G, Damon-Soubeyrand C , Thirouard L , Martinot E , Battistelli E , de Haze A , Bravard S , Tamisier C , Caira F , Coutton C, Barbotin AL, Boursier A, Lakhal L, Beaudoin C , Volle DH
Understanding the role of endocrine disrupting chemicals in testicular germ cell cancer: Insights into molecular mechanisms.
Published on 29 Aug 2024 in Molecular aspects of medicine , vol. 99 - pp 101307
Pang WK , Kuznetsova E , Holota H , De Haze A , Beaudoin C , Volle DH
Increased coral biomineralization due to enhanced symbiotic activity upon volcanic ash exposure
Published on 01 Feb 2024 in Sci Total Environ
Förster F, Reynaud S, Sauzéat L , Ferrier-Pagès C, Samankassou E, Sheldrake TE
Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells.
Published on 01 Nov 2023 in Nanomaterials (Basel).
Bissardon C, Proux O, Gazze SA, Filhol O, Toubhans B, Sauzéat L , Bouchet S, Lewis AR, Maffeis T, Hazemann JL, Bayat S, Cloetens P, Conlan RS, Charlet L, Bohic S.
Identification of the Role of TGR5 in the Regulation of Leydig Cell Homeostasis.
Published on 06 Dec 2022 in International journal of molecular sciences , vol. 23
Holota H , De Haze A , Martinot E , Monrose M , Saru JP , Caira F , Beaudoin C , Volle DH
Metallome deregulation and health-related impacts due to long-term exposure to recent volcanic ash deposits: New chemical and isotopic insights.
Published on 10 Jul 2022 in The Science of the total environment , vol. 829 - pp 154383
Sauzéat L , Eychenne J , Gurioli L, Boyet M, Jessop DE, Moretti R, Monrose M , Holota H , Beaudoin C , Volle DH
Metallome deregulation and health-related impacts due to long-term exposure to recent volcanic ash deposits: New chemical and isotopic insights.
Published on 10 Jul 2022 in The Science of the total environment , vol. 829 - pp 154383
Sauzéat L , Eychenne J , Gurioli L, Boyet M, Jessop DE, Moretti R, Monrose M , Holota H , Beaudoin C , Volle DH
Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance.
Published on 30 Jun 2022 in Advanced science (Weinheim, Baden-Wurttemberg, Germany) , vol. 9 - pp e2200626
Thirouard L , Holota H , Monrose M , Garcia M , de Haze A , Damon-Soubeyrand C, Renaud Y , Saru JP , Perino A, Schoonjans K, Beaudoin C , Volle DH
Intestinal microbiota defines the GUT-TESTIS axis.
Published on 30 Apr 2022 in Gut , vol. 71 - pp 844-845
Martinot E , Thirouard L , Holota H , Monrose M , Garcia M , Beaudoin C , Volle DH
When idiopathic male infertility is rooted in maternal malnutrition during the perinatal period in mice†.
Published on 19 Mar 2022 in Biology of reproduction , vol. 106 - pp 463-476
Muranishi Y, Parry L, Vachette-Dit-Martin M, Saez F , Coudy-Gandilhon C, Sauvanet P, Volle DH , Tournayre J, Bottari S, Carpentiero F, Martinez G, Muroňová J, Escoffier J, Bruhat A, Maurin AC, Averous J, Arnoult C, Fafournoux P, Jousse C
Analysis of the Reversible Impact of the Chemodrug Busulfan on Mouse Testes.
Published on 13 Sep 2021 in Cells , vol. 10
Thirouard L , Holota H , Monrose M , Garcia M , De Haze A , Saru JP , Caira F , Beaudoin C , Volle DH
Nuclear receptors in physiology and pathophysiology.
Published on 30 Apr 2021 in Molecular aspects of medicine , vol. 78 - pp 100956
New perspectives on PPAR, VDR and FXRα as new actors in testicular pathophysiology.
Published on 30 Apr 2021 in Molecular aspects of medicine , vol. 78 - pp 100886
Monrose M , Thirouard L , Garcia M , Holota H , De Haze A , Caira F , Beaudoin C , Volle DH
Molecular and Cellular Endocrinology: Special issue hypothalomo – Pituitary axis: Roles in integrative physiology and pathophysiologies.
Published on 05 Apr 2021 in Molecular and cellular endocrinology , vol. 525 - pp 111198
Editorial: Bisphenols and Male Reproductive Health.
Published on 01 Oct 2020 in Frontiers in endocrinology , vol. 11 - pp 597609
Barbonetti A, D'Andrea S, Bernabò N, Volle DH
Farnesoid X receptor alpha (FXRα) is a critical actor of the development and pathologies of the male reproductive system.
Published on 30 Dec 2019 in Cellular and molecular life sciences : CMLS , vol. 76 - pp 4849-4859
Garcia M , Thirouard L , Monrose M , Holota H , De Haze A , Caira F , Beaudoin C , Volle DH
Fxralpha gene is a target gene of hCG signaling pathway and represses hCG induced steroidogenesis.
Published on 30 Nov 2019 in The Journal of steroid biochemistry and molecular biology , vol. 194 - pp 105460
Holota H , Thirouard L , Garcia M , Monrose M , de Haze A , Saru JP , Caira F , Beaudoin C , Volle DH
Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases.
Published on 17 Nov 2018 in International journal of molecular sciences , vol. 19
Garcia M , Thirouard L , Sedès L , Monrose M , Holota H , Caira F , Volle DH , Beaudoin C
Multigenerational impacts of bile exposure are mediated by TGR5 signaling pathways.
Published on 15 Nov 2018 in Scientific reports , vol. 8 - pp 16875
Baptissart M , Sèdes L , Holota H , Thirouard L , Martinot E , de Haze A , Rouaisnel B , Caira F , Beaudoin C , Volle DH
Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders.
Published on 09 Oct 2018 in Stem cell reports , vol. 11 - pp 944-958
Sèdes L , Desdoits-Lethimonier C, Rouaisnel B , Holota H , Thirouard L , Lesne L, Damon-Soubeyrand C, Martinot E , Saru JP , Mazaud-Guittot S, Caira F , Beaudoin C , Jégou B, Volle DH
Cholesterol: A Gatekeeper of Male Fertility?
Published on 01 Jul 2018 in Frontiers in endocrinology , vol. 9 - pp 369
Sèdes L , Thirouard L , Maqdasy S , Garcia M , Caira F , Lobaccaro JA, Beaudoin C , Volle DH
Bile acids and male fertility: From mouse to human?
Published on 30 Aug 2017 in Molecular aspects of medicine , vol. 56 - pp 101-109
Sèdes L , Martinot E , Baptissart M , Baron S , Caira F , Beaudoin C , Volle DH
Bile acids and their receptors.
Published on 30 Aug 2017 in Molecular aspects of medicine , vol. 56 - pp 2-9
Martinot E , Sèdes L , Baptissart M , Lobaccaro JM , Caira F , Beaudoin C , Volle DH
Bile acids, roles in integrative physiology and pathophysiology.
Published on 30 Aug 2017 in Molecular aspects of medicine , vol. 56 - pp 1
The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate.
Published on 11 Jul 2017 in Stem cell reports , vol. 9 - pp 315-328
Martinot E , Sèdes L , Baptissart M , Holota H , Rouaisnel B , Damon-Soubeyrand C, De Haze A , Saru JP , Thibault-Carpentier C, Keime C, Lobaccaro JA, Baron S , Benoit G, Caira F , Beaudoin C , Volle DH
ERRα induces H3K9 demethylation by LSD1 to promote cell invasion.
Published on 11 Apr 2017 in Proceedings of the National Academy of Sciences of the United States of America , vol. 114 - pp 3909-3914
Carnesecchi J, Forcet C, Zhang L, Tribollet V, Barenton B, Boudra R , Cerutti C, Billas IM, Sérandour AA, Carroll JS, Beaudoin C , Vanacker JM
Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalpha.
Published on 09 Feb 2017 in Scientific reports , vol. 7 - pp 42182
Martinot E , Baptissart M , Véga A , Sèdes L , Rouaisnel B , Vaz F, Saru JP , de Haze A , Baron S , Caira F , Beaudoin C , Volle DH
Nuclear receptors as pharmacological targets, where are we now?
Published on 30 Oct 2016 in Cellular and molecular life sciences : CMLS , vol. 73 - pp 3777-80
Once and for all, LXRα and LXRβ are gatekeepers of the endocrine system.
Published on 30 Jun 2016 in Molecular aspects of medicine , vol. 49 - pp 31-46
Maqdasy S , Trousson A , Tauveron I , Volle DH , Baron S , Lobaccaro JM
mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation.
Published on 18 May 2016 in Cell cycle (Georgetown, Tex.) , vol. 15 - pp 1352-62
Boudra R , Lagrafeuille R, Lours-Calet C, de Joussineau C , Loubeau-Legros G, Chaveroux C, Saru JP , Baron S , Morel L , Beaudoin C
Bile acid-FXRα pathways regulate male sexual maturation in mice.
Published on 12 Apr 2016 in Oncotarget , vol. 7 - pp 19468-82
Baptissart M , Martinot E , Vega A , Sédes L , Rouaisnel B , de Haze A , Baron S , Schoonjans K, Caira F , Volle DH
STAT3 Serine 727 Phosphorylation: A Relevant Target to Radiosensitize Human Glioblastoma.
Published on 30 Jan 2016 in Brain pathology (Zurich, Switzerland) , vol. 26 - pp 18-30
Ouédraogo ZG, Müller-Barthélémy M, Kemeny JL, Dedieu V, Biau J, Khalil T, Raoelfils LI, Granzotto A, Pereira B, Beaudoin C , Guissou IP, Berger M, Morel L , Chautard E, Verrelle P
Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context.
Published on 01 Oct 2015 in PloS one , vol. 10 - pp e0139946
Vega A , Martinot E , Baptissart M , De Haze A , Vaz F, Kulik W, Damon-Soubeyrand C, Baron S , Caira F , Volle DH
Enolase is regulated by Liver X Receptors.
Published on 30 Jul 2015 in Steroids , vol. 99 - pp 266-71
De Boussac H , Maqdasy S , Trousson A , Zelcer N, Volle DH , Lobaccaro JM , Baron S
Identification of the link between the hypothalamo-pituitary axis and the testicular orphan nuclear receptor NR0B2 in adult male mice.
Published on 02 Mar 2015 in Endocrinology , vol. 156 - pp 660-9
Vega A , Martinot E , Baptissart M , De Haze A , Saru JP , Baron S , Caira F , Schoonjans K, Lobaccaro JM , Volle DH
Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP.
Published on 30 Dec 2014 in Expert opinion on therapeutic targets , vol. 18 - pp 1367-76
Vega A , Baptissart M , Martinot E , Saru JP , Baron S , Schoonjans K, Volle DH
Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice.
Published on 30 Sep 2014 in Hepatology (Baltimore, Md.) , vol. 60 - pp 1054-65
Baptissart M , Vega A , Martinot E , Pommier AJ, Houten SM, Marceau G , de Haze A , Baron S , Schoonjans K, Lobaccaro JM , Volle DH
Levels of liver X receptors in testicular biopsies of patients with azoospermia.
Published on 30 Aug 2014 in Fertility and sterility , vol. 102 - pp 361-371.e5
Rondanino C , Ouchchane L, Chauffour C, Marceau G , Déchelotte P , Sion B, Pons-Rejraji H , Janny L , Volle DH , Lobaccaro JM , Brugnon F
NPM1 silencing reduces tumour growth and MAPK signalling in prostate cancer cells.
Published on 05 May 2014 in PloS one , vol. 9 - pp e96293
Loubeau G, Boudra R , Maquaire S, Lours-Calet C, Beaudoin C , Verrelle P, Morel L
Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology.
Published on 11 Apr 2014 in Biochemical and biophysical research communications , vol. 446 - pp 656-62
Oumeddour A , Viennois E, Caira F , Decourbey C, Maqdasy S , Tahraoui A, Baron S , Volle DH , Lobaccaro JM
Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?
Published on 30 Dec 2013 in Cellular and molecular life sciences : CMLS , vol. 70 - pp 4511-26
Baptissart M , Vega A , Martinot E , Baron S , Lobaccaro JM , Volle DH
Oxysterol receptors and their therapeutic applications in cancer conditions.
Published on 30 Sep 2013 in Expert opinion on therapeutic targets , vol. 17 - pp 1029-38
De Boussac H , Alioui A , Viennois E, Dufour J , Trousson A , Vega A , Guy L, Volle DH , Lobaccaro JM , Baron S
Lipids, LXRs and prostate cancer: are HDACs a new link?
Published on 01 Jul 2013 in Biochemical pharmacology , vol. 86 - pp 168-74
Hoang JJ, Baron S , Volle DH , Lobaccaro JM , Trousson A
Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.
Published on 30 May 2013 in PLoS genetics , vol. 9 - pp e1003483
Pommier AJ, Dufour J , Alves G, Viennois E, De Boussac H , Trousson A , Volle DH , Caira F , Val P , Arnaud P , Lobaccaro JM , Baron S
Emerging roles for LXRs and LRH-1 in female reproduction.
Published on 10 Apr 2013 in Molecular and cellular endocrinology , vol. 368 - pp 47-58
Mouzat K, Baron S , Marceau G , Caira F , Sapin V , Volle DH , Lumbroso S, Lobaccaro JM
Cholesterol and male fertility: what about orphans and adopted?
Published on 10 Apr 2013 in Molecular and cellular endocrinology , vol. 368 - pp 30-46
Maqdasy S , Baptissart M , Vega A , Baron S , Lobaccaro JM , Volle DH
Male fertility: Is spermiogenesis the critical step for answering biomedical issues?
Published on 01 Apr 2013 in Spermatogenesis , vol. 3 - pp e24114
Baptissart M , Vega A , Martinot E , Volle DH
Bile acids: from digestion to cancers.
Published on 30 Mar 2013 in Biochimie , vol. 95 - pp 504-17
Baptissart M , Vega A , Maqdasy S , Caira F , Baron S , Lobaccaro JM , Volle DH
LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.
Published on 01 Mar 2013 in American journal of cancer research , vol. 3 - pp 58-69
de Boussac H , Pommier AJ, Dufour J , Trousson A , Caira F , Volle DH , Baron S , Lobaccaro JM
Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell.
Published on 01 Jan 2013 in PloS one , vol. 8 - pp e58876
Dufour J , Pommier A, Alves G, De Boussac H , Lours-Calet C, Volle DH , Lobaccaro JM , Baron S
Epigenetic: a molecular link between testicular cancer and environmental exposures.
Published on 01 Nov 2012 in Frontiers in endocrinology , vol. 3 - pp 150
Vega A , Baptissart M , Caira F , Brugnon F , Lobaccaro JM , Volle DH
Vitamin E: potential therapeutical approach for prevention of liver cancer development.
Published on 30 Sep 2012 in Chinese clinical oncology , vol. 1 - pp 6
Regenerating I messenger RNA and protein expression in the failing human testis: a potential molecular prognostic marker of seminoma.
Published on 30 Dec 2011 in Human pathology , vol. 42 - pp 1841-8
Mauro V, Volle DH , Chevallier D, Haudebourg J, Sénégas-Balas F, Pointis G
Liver X receptors, lipids and their reproductive secrets in the male.
Published on 30 Aug 2011 in Biochimica et biophysica acta , vol. 1812 - pp 974-81
El-Hajjaji FZ, Oumeddour A , Pommier AJ, Ouvrier A, Viennois E, Dufour J , Caira F , Drevet JR, Volle DH , Baron S , Saez F , Lobaccaro JM
Targeting liver X receptors in human health: deadlock or promising trail?
Published on 02 Mar 2011 in Expert opinion on therapeutic targets , vol. 15 - pp 219-32
Viennois E, Pommier AJ, Mouzat K, Oumeddour A , El Hajjaji FZ, Dufour J , Caira F , Volle DH , Baron S , Lobaccaro JM
[Endocrine disruptors and fertility: NR0B2, a new therapeutic target?].
Published on 30 Apr 2010 in Medecine sciences : M/S , vol. 26 - pp 359-61
Decourteix M, Volle DH
The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice.
Published on 30 Dec 2009 in The Journal of clinical investigation , vol. 119 - pp 3752-64
Volle DH , Decourteix M, Garo E, McNeilly J, Fenichel P, Auwerx J, McNeilly AS, Schoonjans K, Benahmed M
Metal-NHC complexes: a survey of anti-cancer properties.
Published on 21 Sep 2009 in Dalton transactions (Cambridge, England : 2003) - pp 6894-902
Teyssot ML, Jarrousse AS, Manin M, Chevry A, Roche S, Norre F, Beaudoin C , Morel L , Boyer D, Mahiou R, Gautier A
Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.
Published on 30 Jul 2009 in Endocrinology , vol. 150 - pp 3369-75
Mouzat K, Volat F, Baron S , Alves G, Pommier AJ, Volle DH , Marceau G , DeHaze A, Déchelotte P , Duggavathi R, Caira F , Lobaccaro JM
[NPM: a new player in prostate cancer?].
Published on 30 Jan 2009 in Medecine sciences : M/S , vol. 25 - pp 19-21
Beaudoin C , Maquaire S, Léotoing L, Allemand J, Lours-Calet C, Veyssière G, Manin M, Morel L
Toxicity of copper(I)-NHC complexes against human tumor cells: induction of cell cycle arrest, apoptosis, and DNA cleavage.
Published on 01 Jan 2009 in Chemistry (Weinheim an der Bergstrasse, Germany) , vol. 15 - pp 314-8
Teyssot ML, Jarrousse AS, Chevry A, De Haze A , Beaudoin C , Manin M, Nolan SP, Díez-González S, Morel L , Gautier A
Liver receptor homolog 1 is essential for ovulation.
Published on 15 Jul 2008 in Genes & development , vol. 22 - pp 1871-6
Duggavathi R, Volle DH , Mataki C, Antal MC, Messaddeq N, Auwerx J, Murphy BD, Schoonjans K
Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR.
Published on 30 Jun 2008 in Biology of reproduction , vol. 78 - pp 968-75
Henry-Berger J , Mouzat K, Baron S , Bernabeu C, Marceau G , Saru JP , Sapin V , Lobaccaro JM , Caira F
Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell.
Published on 01 May 2008 in Oncogene , vol. 27 - pp 2858-67
Léotoing L, Meunier L, Manin M, Mauduit C, Decaussin M, Verrijdt G, Claessens F, Benahmed M, Veyssière G, Morel L , Beaudoin C
