Jean-Marc LOBACCARO
Chef d'équipe
LOBACCARO
Jean-Marc
Chef d'équipe
Professeur des Universités
Resume
Jean-Marc A. LOBACCARO
Born 27/12/1965
Université Clermont Auvergne (UCA)
Institut “Génétique, Reproduction, Développement”
+33 (0)463 407 416 / +33 (0)662 138 591 j-marc.lobaccaro@uca.fr
Language skills
French: mother tongue – Italian: father tongue – English: C1/C2
Education and Professional activities
Since sept. 2021 - Director of Institut “Sciences, Vie, Santé, Agronomie, Environnement
2017-2021 - vice Dean Faculty Biology, in charge of the Research. UCA
2017-now - Full-professor Hors Class (Equivalent Distinguished professor)
2017 January-July - Visiting professor. Pr. Moschetta’s Lab. Interdisciplinary Department of Medicine, Bari, Italy
1999 – now Full-professor of Molecular Physiology (Université Blaise Pascal; Group leader). Since 2017, Professor of exceptional class. Holder of a bonus for scientific excellence since 2000.
1997-1999 - Research Associate Howard Hugues Medical Institute (UTSWMC, Dallas, TX)
1992-1996 - post-doctoral researcher in pharmaceutical industry (INSERM, Montpellier)
1996 - Habilitation to Direct Research in Biochemisty and Molecular Biology (Université de Montpellier)
1988-1992 – PhD in Reproduction and Developmental Biology (Université de Montpellier)
1987-1988 – DEA (eq. Master ) in Reproduction and Developmental Biology (Université de Montpellier)
International expertise
French ministry for Research and international cooperation since2004; MIUR since 2004 for endocrinology, cancer, signalisation, lipids; Flamish foundation for research (2012-2018) for cancer; Scientific council of the French-Italian University (2015-2019); Member of the International Board of expertise for the Doctoral School in Health Sciences and Life of the National University of Mongolia (2019), Yerevan State University (2020) and Research International Center of the National Academy of Sciences of Armenia (2021); Member of the International Board of expertise for Fundamentals of applied life sciences and biotechnology of the National Scientific Center of Poland (since 2020).
International recognition and awards
Since 2021: Collegio del Dottorato di ricerca in “Metabolism, Aging and Social Medicine”. University of Bari, Italy
2018-2020 - Adjunct Professor of the Department of Physiology. University of Bari, Italy
2017 - Knight of the Academic Palms from the French Ministry of Education and Research
2010 - Bronze medal of the City of Clermont-Ferrand
2002 - Poster price Vo Congresso Società Italiana di Andrologia Medica, Catania, Italy
1998 - Travel Award 80th Annual Meeting of the Endocrine Society, New-Orleans, LA
1996 - Young researcher awaræd, French Society for Endocrinology
1995 and 1996 - Henning Andersen Prize of Annual Meeting of the European Society for Pædiatric Endocrinology
Scientific outcomes
ORCID: 0000-0001-9890-2392
173 international scientific articles – 7800 citations (without self-citation) - H index (WoS) = 39.
Ongoing research projects
* Synthetic derivatives of flavonoids for the treatment of metastatic prostate cancer (Cancer associations)
* Identification of natural extracts targeting LXR activity for skin wound healing (Industrial project)
Selected publication since 2018 (Names of supervised students have been underlined)
Bayala B, … Lobaccaro JMA. Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule. Biochimie 2018; 153: 162-170.
Ducheix S, Peres C, Hardfeldht J, Frau C, Mocciaro G, Piccinin E, Lobaccaro JM, Plateroti M, Griffin JL, Ntambi J, Moschetta A. Ablation of stearoyl-CoA desaturase 1 in enterocytes drives intestinal inflammation and tumorigenesis that are rescued by dietary oleate. Gastroenterology, 2018; 155: 1524–1538.e9.
Dallel S, … Lobaccaro JMA*, Maqdasy S. Liver X Receptors: a Possible Link between Lipid Disorders and Female Infertility. Int J Mol Sci 2018. Jul 25;19(8).
Bousset B, … Lobaccaro JMA*, et al. New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors. Int J Mol Sci. 2018, 19, 2545
Cariello M, … Moschetta A, Lobaccaro JMA. LXRs, SHP and FXR in prostate cancer: enemies or Ménage-à-quatre with AR? Nuclear Receptor Signaling. 2018 Oct 16;15:1550762918801070.
Zabaiou N, Fouache A, … Lobaccaro JMA*. Ethanolic extract of Algerian propolis decreases androgen receptor transcriptional activity in cultured LNCaP cells. J Steroid Biochem Mol Biol. 2019;189:108-115.
Celhay O, …, Lobaccaro JMA, Baron S. Individual comparison of cholesterol metabolism in normal and tumour areas in radical prostatectomy specimens for time. Eur Urol Oncol. 2019 Mar;2(2):198-206.
Fouache A, Zabaiou N, … Lobaccaro JMA*, Trousson A. Flavonoids differentially modulate Liver X Receptors activity. Structure-function relationship analysis. J Steroid Biochem Mol Biol. 2019 Jun;190:173-18
Rambur A, Lours-Calet C, Buñay J, … Lobaccaro JMA, et al.. Sequential recruitment of Ras/MAPK and PI3K/AKT/mTOR pathways drives basal extrusion in the prostate-like gland of the Drosophila. Nature Commun 2020; 11(1):2300.
Bousset L, Septier A, Bunay J, … Lobaccaro JMA, et al. Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia. PLOS Biol 2020. Dec 7;18(12):e3000948.
Buñay J, Fouache A, … Morel L, Baron S, Lobaccaro JMA*. Screening for Liver X Receptor modulators: where are we and for what use? British J Pharmacol 2021 Aug;178(16):3277-3293.
Rambur A, … Lobaccaro JM, et al. Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer. Cells. 2021 Sep 10;10(9):2387.
Ducheix S, Piccinin E, Peres C, Garcia-Irigoyen O, Bertrand-Michel J, Fouache A, Cariello M, Lobaccaro JMA, Guillou H, Carlo Sabbà, Ntambi J, Moschetta A. Reduction in gut-derived MUFAs via intestinal stearoyl-CoA desaturase 1 deletion drives susceptibility to NAFLD and hepatocarcinoma. Hepatology Communications, 2022;00:1-13.
Lobasso S, Lobaccaro JMA, Angelini R. Editorial: The multifaceted roles of lipids in physiological and pathophysiological states. Front Physiol. 2022 13:930962. https://doi.org/10.3389/fphys.2022.930962
Publications
Liver X Receptors Enhance Epithelial to Mesenchymal Transition in Metastatic Prostate Cancer Cells.
Published on 06 Aug 2024 in Cancers , vol. 16
Bouchareb E , Dallel S , De Haze A , Damon-Soubeyrand C , Renaud Y , Baabdaty E , Vialat M , Fabre J , Pouchin P , De Joussineau C , Degoul F , Sanmukh S, Gendronneau J , Sanchez P, Gonthier-Gueret C, Trousson A , Morel L , Lobaccaro JM , Kocer A , Baron S
Persistent organic pollutants promote aggressiveness in prostate cancer.
Published on 01 Sep 2023 in Oncogene , vol. 42 - pp 2854-2867
Buñay J, Kossai M, Damon-Soubeyrant C, De Haze A , Saru JP , Trousson A , de Joussineau C , Bouchareb E , Kocer A , Vialat M , Dallel S , Degoul F , Bost F, Clavel S, Penault-Llorca F, Valli MP, Guy L, Matthews J, Renaud Y , Ittmann M, Jones J, Morel L , Lobaccaro JM , Baron S
MEN1 silencing aggravates tumorigenic potential of AR-independent prostate cancer cells through nuclear translocation and activation of JunD and β-catenin.
Published on 26 Aug 2021 in Journal of experimental & clinical cancer research : CR , vol. 40 - pp 270
Luo Y, Vlaeminck-Guillem V, Baron S , Dallel S , Zhang CX, Le Romancer M
Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer.
Published on 10 Sep 2021 in Cells , vol. 10
Rambur A , Vialat M , Beaudoin C , Lours-Calet C, Lobaccaro JM , Baron S , Morel L , de Joussineau C
Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila.
Published on 08 May 2020 in Nature communications , vol. 11 - pp 2300
Rambur A , Lours-Calet C, Beaudoin C , Buñay J, Vialat M , Mirouse V , Trousson A , Renaud Y , Lobaccaro JA, Baron S , Morel L , de Joussineau C
Individual Comparison of Cholesterol Metabolism in Normal and Tumour Areas in Radical Prostatectomy Specimens from Patients with Prostate Cancer: Results of the CHOMECAP Study.
Published on 30 Mar 2019 in European urology oncology , vol. 2 - pp 198-206
Celhay O , Bousset L , Guy L, Kemeny JL, Leoni V, Caccia C, Trousson A , Damon-Soubeyrant C, De Haze A , Sabourin L, Godfraind C, de Joussineau C , Pereira B, Morel L , Lobaccaro JM , Baron S
Cholesterol: A Gatekeeper of Male Fertility?
Published on 01 Jul 2018 in Frontiers in endocrinology , vol. 9 - pp 369
Sèdes L , Thirouard L , Maqdasy S , Garcia M , Caira F , Lobaccaro JA, Beaudoin C , Volle DH
Dual extraction of mRNA and lipids from a single biological sample.
Published on 04 May 2018 in Scientific reports , vol. 8 - pp 7019
Podechard N, Ducheix S, Polizzi A, Lasserre F, Montagner A, Legagneux V, Fouché E, Saez F , Lobaccaro JM , Lakhal L, Ellero-Simatos S, Martin PG, Loiseau N, Bertrand-Michel J, Guillou H
Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule.
Published on 30 Oct 2018 in Biochimie , vol. 153 - pp 162-170
Bayala B , Bassole IHN, Maqdasy S , Baron S , Simpore J, Lobaccaro JA
Liver X Receptors: A Possible Link between Lipid Disorders and Female Infertility.
Published on 25 Jul 2018 in International journal of molecular sciences , vol. 19
Dallel S , Tauveron I , Brugnon F , Baron S , Lobaccaro JMA, Maqdasy S
New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors.
Published on 28 Aug 2018 in International journal of molecular sciences , vol. 19
Bousset L , Rambur A , Fouache A , Bunay J, Morel L , Lobaccaro JA, Baron S , Trousson A , de Joussineau C
Dendrogenin A drives LXR to trigger lethal autophagy in cancers.
Published on 04 Dec 2017 in Nature communications , vol. 8 - pp 1903
Segala G, David M, de Medina P, Poirot MC, Serhan N, Vergez F, Mougel A, Saland E, Carayon K, Leignadier J, Caron N, Voisin M , Cherier J, Ligat L, Lopez F, Noguer E, Rives A, Payré B, Saati TA, Lamaziere A, Despres G, Lobaccaro JM , Baron S , Demur C, de Toni F, Larrue C, Boutzen H, Thomas F, Sarry JE, Tosolini M, Picard D, Record M, Récher C, Poirot M, Silvente-Poirot S
Bile acids and their receptors.
Published on 30 Aug 2017 in Molecular aspects of medicine , vol. 56 - pp 2-9
Martinot E , Sèdes L , Baptissart M , Lobaccaro JM , Caira F , Beaudoin C , Volle DH
Biological properties of propolis extracts: Something new from an ancient product.
Published on 30 Oct 2017 in Chemistry and physics of lipids , vol. 207 - pp 214-222
Zabaiou N , Fouache A , Trousson A , Baron S , Zellagui A, Lahouel M , Lobaccaro JA
Role of the liver X receptors in skin physiology: Putative pharmacological targets in human diseases.
Published on 30 Oct 2017 in Chemistry and physics of lipids , vol. 207 - pp 59-68
Ouedraogo ZG, Fouache A , Trousson A , Baron S , Lobaccaro JA
Lipid Homeostasis and Ligands for Liver X Receptors: Identification and Characterization.
Published on 01 Jan 2016 in Methods in molecular biology (Clifton, N.J.) , vol. 1443 - pp 13-9
Lobaccaro JM , Beaudoin C , Bayala B , Baron S , Trousson A
Once and for all, LXRα and LXRβ are gatekeepers of the endocrine system.
Published on 30 Jun 2016 in Molecular aspects of medicine , vol. 49 - pp 31-46
Maqdasy S , Trousson A , Tauveron I , Volle DH , Baron S , Lobaccaro JM
Oxidative stress in benign prostate hyperplasia.
Published on 01 Mar 2016 in Andrologia , vol. 48 - pp 69-73
Zabaiou N , Mabed D, Lobaccaro JM , Lahouel M
Identification of the Functions of Liver X Receptor-β in Sertoli Cells Using a Targeted Expression-Rescue Model.
Published on 30 Dec 2015 in Endocrinology , vol. 156 - pp 4545-57
Maqdasy S , El Hajjaji FZ, Baptissart M , Viennois E, Oumeddour A , Brugnon F , Trousson A , Tauveron I , Volle D, Lobaccaro JM , Baron S
Enolase is regulated by Liver X Receptors.
Published on 30 Jul 2015 in Steroids , vol. 99 - pp 266-71
De Boussac H , Maqdasy S , Trousson A , Zelcer N, Volle DH , Lobaccaro JM , Baron S
Identification of the link between the hypothalamo-pituitary axis and the testicular orphan nuclear receptor NR0B2 in adult male mice.
Published on 02 Mar 2015 in Endocrinology , vol. 156 - pp 660-9
Vega A , Martinot E , Baptissart M , De Haze A , Saru JP , Baron S , Caira F , Schoonjans K, Lobaccaro JM , Volle DH
Liver X receptor activation promotes polyunsaturated fatty acid synthesis in macrophages: relevance in the context of atherosclerosis.
Published on 30 Jun 2015 in Arteriosclerosis, thrombosis, and vascular biology , vol. 35 - pp 1357-65
Varin A, Thomas C, Ishibashi M, Ménégaut L, Gautier T, Trousson A , Bergas V, de Barros JP, Narce M, Lobaccaro JM , Lagrost L, Masson D
Comparaison appariée des flux du cholestérol cellulaire dans les tissus sains et cancéreux prostatiques : résultats de l’étude Chomecap.
Published on 30 Nov 2015 in Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie , vol. 25 - pp 727-8
Celhay O , Laurent G, Alioui A , Trousson A , Kemeny L, Pereira B, Leoni V, Lobaccaro J, Baron S
Anticancer activity of essential oils and their chemical components – a review.
Published on 19 Nov 2014 in American journal of cancer research , vol. 4 - pp 591-607
Bayala B , Bassole IH, Scifo R, Gnoula C, Morel L , Lobaccaro JM , Simpore J
Chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils of plants from Burkina Faso.
Published on 24 Mar 2014 in PloS one , vol. 9 - pp e92122
Bayala B , Bassole IH, Gnoula C, Nebie R, Yonli A, Morel L , Figueredo G, Nikiema JB, Lobaccaro JM , Simpore J
Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice.
Published on 30 Sep 2014 in Hepatology (Baltimore, Md.) , vol. 60 - pp 1054-65
Baptissart M , Vega A , Martinot E , Pommier AJ, Houten SM, Marceau G , de Haze A , Baron S , Schoonjans K, Lobaccaro JM , Volle DH
Levels of liver X receptors in testicular biopsies of patients with azoospermia.
Published on 30 Aug 2014 in Fertility and sterility , vol. 102 - pp 361-371.e5
Rondanino C , Ouchchane L, Chauffour C, Marceau G , Déchelotte P , Sion B, Pons-Rejraji H , Janny L , Volle DH , Lobaccaro JM , Brugnon F
Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology.
Published on 11 Apr 2014 in Biochemical and biophysical research communications , vol. 446 - pp 656-62
Oumeddour A , Viennois E, Caira F , Decourbey C, Maqdasy S , Tahraoui A, Baron S , Volle DH , Lobaccaro JM
Environmental estrogen exposure during fetal life: a time bomb for prostate cancer.
Published on 30 Mar 2014 in Endocrinology , vol. 155 - pp 656-8
Lipids, LXRs and prostate cancer: are HDACs a new link?
Published on 01 Jul 2013 in Biochemical pharmacology , vol. 86 - pp 168-74
Hoang JJ, Baron S , Volle DH , Lobaccaro JM , Trousson A
Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell.
Published on 01 Jan 2013 in PloS one , vol. 8 - pp e58876
Dufour J , Pommier A, Alves G, De Boussac H , Lours-Calet C, Volle DH , Lobaccaro JM , Baron S
Oxysterol receptors and their therapeutic applications in cancer conditions.
Published on 30 Sep 2013 in Expert opinion on therapeutic targets , vol. 17 - pp 1029-38
De Boussac H , Alioui A , Viennois E, Dufour J , Trousson A , Vega A , Guy L, Volle DH , Lobaccaro JM , Baron S
Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?
Published on 30 Dec 2013 in Cellular and molecular life sciences : CMLS , vol. 70 - pp 4511-26
Baptissart M , Vega A , Martinot E , Baron S , Lobaccaro JM , Volle DH
Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.
Published on 30 May 2013 in PLoS genetics , vol. 9 - pp e1003483
Pommier AJ, Dufour J , Alves G, Viennois E, De Boussac H , Trousson A , Volle DH , Caira F , Val P , Arnaud P , Lobaccaro JM , Baron S
LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.
Published on 01 Mar 2013 in American journal of cancer research , vol. 3 - pp 58-69
de Boussac H , Pommier AJ, Dufour J , Trousson A , Caira F , Volle DH , Baron S , Lobaccaro JM
Cholesterol and male fertility: what about orphans and adopted?
Published on 10 Apr 2013 in Molecular and cellular endocrinology , vol. 368 - pp 30-46
Maqdasy S , Baptissart M , Vega A , Baron S , Lobaccaro JM , Volle DH
Bile acids: from digestion to cancers.
Published on 30 Mar 2013 in Biochimie , vol. 95 - pp 504-17
Baptissart M , Vega A , Maqdasy S , Caira F , Baron S , Lobaccaro JM , Volle DH
Emerging roles for LXRs and LRH-1 in female reproduction.
Published on 10 Apr 2013 in Molecular and cellular endocrinology , vol. 368 - pp 47-58
Mouzat K, Baron S , Marceau G , Caira F , Sapin V , Volle DH , Lumbroso S, Lobaccaro JM
A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα.
Published on 30 Mar 2013 in Biochimie , vol. 95 - pp 556-67
Ducheix S, Podechard N, Lasserre F, Polizzi A, Pommier A, Murzilli S, Di Lisio C, D'Amore S, Bertrand-Michel J, Montagner A, Pineau T, Loiseau N, Lobaccaro JM , Martin PG, Guillou H
Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.
Published on 30 May 2013 in Journal of hepatology , vol. 58 - pp 984-92
Ducheix S, Montagner A, Polizzi A, Lasserre F, Marmugi A, Bertrand-Michel J, Podechard N, Al Saati T, Chétiveaux M, Baron S , Boué J, Dietrich G, Mselli-Lakhal L, Costet P, Lobaccaro JM , Pineau T, Theodorou V, Postic C, Martin PG, Guillou H
Liver X Receptors and female reproduction: when cholesterol meets fertility!
Published on 30 Jan 2013 in Journal of endocrinological investigation , vol. 36 - pp 55-60
Lobaccaro JM , Gallot D , Lumbroso S, Mouzat K
Vitamin E: potential therapeutical approach for prevention of liver cancer development.
Published on 30 Sep 2012 in Chinese clinical oncology , vol. 1 - pp 6
Epigenetic: a molecular link between testicular cancer and environmental exposures.
Published on 01 Nov 2012 in Frontiers in endocrinology , vol. 3 - pp 150
Vega A , Baptissart M , Caira F , Brugnon F , Lobaccaro JM , Volle DH
Selective liver X receptor modulators (SLiMs): what use in human health?
Published on 04 Apr 2012 in Molecular and cellular endocrinology , vol. 351 - pp 129-41
Viennois E, Mouzat K, Dufour J , Morel L , Lobaccaro JM , Baron S
Lxrα regulates the androgen response in prostate epithelium.
Published on 30 Jul 2012 in Endocrinology , vol. 153 - pp 3211-23
Viennois E, Esposito T, Dufour J , Pommier A, Fabre S, Kemeny JL, Guy L, Morel L , Lobaccaro JM , Baron S
Oxysterol receptors, AKT and prostate cancer.
Published on 30 Dec 2012 in Current opinion in pharmacology , vol. 12 - pp 724-8
Dufour J , Viennois E, De Boussac H , Baron S , Lobaccaro JM
Liver X receptors, lipids and their reproductive secrets in the male.
Published on 01 Aug 2011 in Biochimica et biophysica acta , vol. 1812 - pp 974-81
El-Hajjaji FZ, Oumeddour A , Pommier AJ, Ouvrier A, Viennois E, Dufour J , Caira F , Drevet JR , Volle DH, Baron S , Saez F , Lobaccaro JM
Dietary cholesterol-induced post-testicular infertility.
Published on 01 Jan 2011 in PloS one , vol. 6 - pp e26966
Ouvrier A, Alves G, Damon-Soubeyrand C , Marceau G , Cadet R , Janny L , Brugnon F , Kocer A , Pommier A, Lobaccaro JM , Drevet JR , Saez F
Liver X receptors, lipids and their reproductive secrets in the male.
Published on 30 Aug 2011 in Biochimica et biophysica acta , vol. 1812 - pp 974-81
El-Hajjaji FZ, Oumeddour A , Pommier AJ, Ouvrier A, Viennois E, Dufour J , Caira F , Drevet JR, Volle DH , Baron S , Saez F , Lobaccaro JM
Targeting liver X receptors in human health: deadlock or promising trail?
Published on 02 Mar 2011 in Expert opinion on therapeutic targets , vol. 15 - pp 219-32
Viennois E, Pommier AJ, Mouzat K, Oumeddour A , El Hajjaji FZ, Dufour J , Caira F , Volle DH , Baron S , Lobaccaro JM
Liver X Receptor: an oxysterol sensor and a major player in the control of lipogenesis.
Published on 30 Sep 2011 in Chemistry and physics of lipids , vol. 164 - pp 500-14
Ducheix S, Lobaccaro JM , Martin PG, Guillou H
Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols.
Published on 29 Jun 2011 in The Journal of neuroscience : the official journal of the Society for Neuroscience , vol. 31 - pp 9620-9
Makoukji J, Shackleford G, Meffre D, Grenier J, Liere P, Lobaccaro JM , Schumacher M, Massaad C
Differential effects of lycopene consumed in tomato paste and lycopene in the form of a purified extract on target genes of cancer prostatic cells.
Published on 30 Jun 2010 in The American journal of clinical nutrition , vol. 91 - pp 1716-24
Talvas J, Caris-Veyrat C, Guy L, Rambeau M, Lyan B, Minet-Quinard R , Lobaccaro JM , Vasson MP, Georgé S, Mazur A, Rock E
Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.
Published on 06 May 2010 in Oncogene , vol. 29 - pp 2712-23
Pommier AJ, Alves G, Viennois E, Bernard S, Communal Y, Sion B, Marceau G , Damon C, Mouzat K, Caira F , Baron S , Lobaccaro JM
Thyroid hormone receptor beta (TRbeta) and liver X receptor (LXR) regulate carbohydrate-response element-binding protein (ChREBP) expression in a tissue-selective manner.
Published on 03 Sep 2010 in The Journal of biological chemistry , vol. 285 - pp 28156-63
Gauthier K, Billon C, Bissler M, Beylot M, Lobaccaro JM , Vanacker JM, Samarut J
Estrogens repress PGC1-α expression in the uterus.
Published on 15 Dec 2010 in Molecular and cellular endocrinology , vol. 330 - pp 33-40
Macari C, Teyssier C, Tribollet V, Mouzat K, Forcet C, Horard B, Lobaccaro JM , Vanacker JM
LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner.
Published on 01 Sep 2009 in Journal of lipid research , vol. 50 - pp 1766-75
Ouvrier A, Cadet R , Vernet P, Laillet B, Chardigny JM, Lobaccaro JM , Drevet JR , Saez F
LXR regulate cholesterol homeostasis in the proximal mouse epididymis.
Published on 01 Jan 2009 in Folia histochemica et cytobiologica , vol. 47 - pp S75-9
Ouvrier A, Cadet R , Lobaccaro JM , Drevet JR , Saez F
Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.
Published on 30 Jul 2009 in Endocrinology , vol. 150 - pp 3369-75
Mouzat K, Volat F, Baron S , Alves G, Pommier AJ, Volle DH , Marceau G , DeHaze A, Déchelotte P , Duggavathi R, Caira F , Lobaccaro JM
Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages.
Published on 14 Aug 2009 in Circulation research , vol. 105 - pp 393-401
Rébé C, Raveneau M, Chevriaux A, Lakomy D, Sberna AL, Costa A, Bessède G, Athias A, Steinmetz E, Lobaccaro JM , Alves G, Menicacci A, Vachenc S, Solary E, Gambert P, Masson D
[Nuclear liver X receptors are involved in the biology of reproduction].
Published on 02 Mar 2009 in Medecine sciences : M/S , vol. 25 - pp 141-4
Mouzat K, Alves G, Pommier A, Viennois E, Pihen T, Caira F , Baron S , A Lobaccaro JM
25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.
Published on 30 May 2009 in Journal of neurochemistry , vol. 109 - pp 945-58
Trousson A , Bernard S, Petit PX, Liere P, Pianos A, El Hadri K, Lobaccaro JM , Ghandour MS, Raymondjean M, Schumacher M, Massaad C
Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR.
Published on 30 Jun 2008 in Biology of reproduction , vol. 78 - pp 968-75
Henry-Berger J , Mouzat K, Baron S , Bernabeu C, Marceau G , Saru JP , Sapin V , Lobaccaro JM , Caira F
A specialized cDNA microarray (Mouse Lipid Chip) reveals hepatic overexpression of serum amyloid a in high-fat diet-fed mice.
Published on 30 Mar 2008 in Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme , vol. 40 - pp 228-30
Dejeans N, Auclair S, Henry-Berger J , Lobaccaro JM , Mazur A
Liver X receptors and epididymal epithelium physiology.
Published on 01 Jul 2007 in Asian journal of andrology , vol. 9 - pp 574-82
Saez F , Chabory E, Cadet R , Vernet P, Baron S , Lobaccaro JM , Drevet JR
The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice.
Published on 01 Feb 2007 in Genes & development , vol. 21 - pp 303-15
Volle DH , Duggavathi R, Magnier BC, Houten SM, Cummins CL, Lobaccaro JM , Verhoeven G, Schoonjans K, Auwerx J
Role of the nuclear receptors for oxysterols LXRs in steroidogenic tissues: beyond the “foie gras”, the steroids and sex?
Published on 02 Mar 2007 in Molecular and cellular endocrinology , vol. 265-266 - pp 183-9
Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility.
Published on 30 May 2007 in Molecular endocrinology (Baltimore, Md.) , vol. 21 - pp 1014-27
Volle DH , Mouzat K, Duggavathi R, Siddeek B, Déchelotte P , Sion B, Veyssière G, Benahmed M, Lobaccaro JM
Liver X receptors and epididymal epithelium physiology.
Published on 30 Jul 2007 in Asian journal of andrology , vol. 9 - pp 574-82
Saez F , Chabory E, Cadet R , Vernet P, Baron S , Lobaccaro JM , Drevet JR
Liver X receptors regulate adrenal cholesterol balance.
Published on 30 Jul 2006 in The Journal of clinical investigation , vol. 116 - pp 1902-12
Cummins CL, Volle DH , Zhang Y, McDonald JG, Sion B, Lefrançois-Martinez AM , Caira F , Veyssière G, Mangelsdorf DJ, Lobaccaro JM
Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development.
Published on 30 Mar 2005 in The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology , vol. 283 - pp 175-81
Marceau G , Volle DH , Gallot D , Mangelsdorf DJ, Sapin V , Lobaccaro JM
Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.
Published on 01 Oct 2004 in Journal of molecular endocrinology , vol. 33 - pp 361-75
Frenoux JM, Vernet P, Volle DH, Britan A, Saez F , Kocer A , Henry-Berger J , Mangelsdorf DJ, Lobaccaro JM , Drevet JR
Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.
Published on 30 Oct 2004 in Journal of molecular endocrinology , vol. 33 - pp 361-75
Frenoux JM, Vernet P, Volle DH , Britan A, Saez F , Kocer A , Henry-Berger J , Mangelsdorf DJ, Lobaccaro JM , Drevet JR
Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes.
Published on 30 Apr 2004 in Molecular endocrinology (Baltimore, Md.) , vol. 18 - pp 888-98
Volle DH , Repa JJ, Mazur A, Cummins CL, Val P , Henry-Berger J , Caira F , Veyssiere G, Mangelsdorf DJ, Lobaccaro JM
[Oxysterols: metabolism, biological role and associated diseases].
Published on 30 Mar 2004 in Gastroenterologie clinique et biologique , vol. 28 - pp 279-93
Souidi M, Dubrac S, Parquet M, Volle DH , Lobaccaro JM , Mathé D, Combes O, Scanff P, Lutton C, Aigueperse J
[Regulation of lipid metabolism by the orphan nuclear receptors].
Published on 30 Jun 2001 in Annales d'endocrinologie , vol. 62 - pp 239-47
Lobaccaro JM , Repa JJ, Lu TT, Caira F , Henry-Berger J , Volle DH , Mangelsdorf DJ
