Jean-Marc A. LOBACCARO
Born 27/12/1965
Université Clermont Auvergne (UCA)
Institut “Génétique, Reproduction, Développement”
+33 (0)463 407 416 / +33 (0)662 138 591 j-marc.lobaccaro@uca.fr
Language skills
French: mother tongue – Italian: father tongue – English: C1/C2
Education and Professional activities
Since sept. 2021 - Director of Institut “Sciences, Vie, Santé, Agronomie, Environnement
2017-2021 - vice Dean Faculty Biology, in charge of the Research. UCA
2017-now - Full-professor Hors Class (Equivalent Distinguished professor)
2017 January-July - Visiting professor. Pr. Moschetta’s Lab. Interdisciplinary Department of Medicine, Bari, Italy
1999 – now Full-professor of Molecular Physiology (Université Blaise Pascal; Group leader). Since 2017, Professor of exceptional class. Holder of a bonus for scientific excellence since 2000.
1997-1999 - Research Associate Howard Hugues Medical Institute (UTSWMC, Dallas, TX)
1992-1996 - post-doctoral researcher in pharmaceutical industry (INSERM, Montpellier)
1996 - Habilitation to Direct Research in Biochemisty and Molecular Biology (Université de Montpellier)
1988-1992 – PhD in Reproduction and Developmental Biology (Université de Montpellier)
1987-1988 – DEA (eq. Master ) in Reproduction and Developmental Biology (Université de Montpellier)
International expertise
French ministry for Research and international cooperation since2004; MIUR since 2004 for endocrinology, cancer, signalisation, lipids; Flamish foundation for research (2012-2018) for cancer; Scientific council of the French-Italian University (2015-2019); Member of the International Board of expertise for the Doctoral School in Health Sciences and Life of the National University of Mongolia (2019), Yerevan State University (2020) and Research International Center of the National Academy of Sciences of Armenia (2021); Member of the International Board of expertise for Fundamentals of applied life sciences and biotechnology of the National Scientific Center of Poland (since 2020).
International recognition and awards
Since 2021: Collegio del Dottorato di ricerca in “Metabolism, Aging and Social Medicine”. University of Bari, Italy
2018-2020 - Adjunct Professor of the Department of Physiology. University of Bari, Italy
2017 - Knight of the Academic Palms from the French Ministry of Education and Research
2010 - Bronze medal of the City of Clermont-Ferrand
2002 - Poster price Vo Congresso Società Italiana di Andrologia Medica, Catania, Italy
1998 - Travel Award 80th Annual Meeting of the Endocrine Society, New-Orleans, LA
1996 - Young researcher awaræd, French Society for Endocrinology
1995 and 1996 - Henning Andersen Prize of Annual Meeting of the European Society for Pædiatric Endocrinology
Scientific outcomes
ORCID: 0000-0001-9890-2392
173 international scientific articles – 7800 citations (without self-citation) - H index (WoS) = 39.
Ongoing research projects
* Synthetic derivatives of flavonoids for the treatment of metastatic prostate cancer (Cancer associations)
* Identification of natural extracts targeting LXR activity for skin wound healing (Industrial project)
Selected publication since 2018 (Names of supervised students have been underlined)

Bayala B, … Lobaccaro JMA. Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule. Biochimie 2018; 153: 162-170.
Ducheix S, Peres C, Hardfeldht J, Frau C, Mocciaro G, Piccinin E, Lobaccaro JM, Plateroti M, Griffin JL, Ntambi J, Moschetta A. Ablation of stearoyl-CoA desaturase 1 in enterocytes drives intestinal inflammation and tumorigenesis that are rescued by dietary oleate. Gastroenterology, 2018; 155: 1524–1538.e9.
Dallel S, … Lobaccaro JMA*, Maqdasy S. Liver X Receptors: a Possible Link between Lipid Disorders and Female Infertility. Int J Mol Sci 2018. Jul 25;19(8).
Bousset B, … Lobaccaro JMA*, et al. New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors. Int J Mol Sci. 2018, 19, 2545
Cariello M, … Moschetta A, Lobaccaro JMA. LXRs, SHP and FXR in prostate cancer: enemies or Ménage-à-quatre with AR? Nuclear Receptor Signaling. 2018 Oct 16;15:1550762918801070.
Zabaiou N, Fouache A, … Lobaccaro JMA*. Ethanolic extract of Algerian propolis decreases androgen receptor transcriptional activity in cultured LNCaP cells. J Steroid Biochem Mol Biol. 2019;189:108-115.
Celhay O, …, Lobaccaro JMA, Baron S. Individual comparison of cholesterol metabolism in normal and tumour areas in radical prostatectomy specimens for time. Eur Urol Oncol. 2019 Mar;2(2):198-206.
Fouache A, Zabaiou N, … Lobaccaro JMA*, Trousson A. Flavonoids differentially modulate Liver X Receptors activity. Structure-function relationship analysis. J Steroid Biochem Mol Biol. 2019 Jun;190:173-18
Rambur A, Lours-Calet C, Buñay J, … Lobaccaro JMA, et al.. Sequential recruitment of Ras/MAPK and PI3K/AKT/mTOR pathways drives basal extrusion in the prostate-like gland of the Drosophila. Nature Commun 2020; 11(1):2300.
Bousset L, Septier A, Bunay J, … Lobaccaro JMA, et al. Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia. PLOS Biol 2020. Dec 7;18(12):e3000948.
Buñay J, Fouache A, … Morel L, Baron S, Lobaccaro JMA*. Screening for Liver X Receptor modulators: where are we and for what use? British J Pharmacol 2021 Aug;178(16):3277-3293.
Rambur A, … Lobaccaro JM, et al. Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer. Cells. 2021 Sep 10;10(9):2387.
Ducheix S, Piccinin E, Peres C, Garcia-Irigoyen O, Bertrand-Michel J, Fouache A, Cariello M, Lobaccaro JMA, Guillou H, Carlo Sabbà, Ntambi J, Moschetta A. Reduction in gut-derived MUFAs via intestinal stearoyl-CoA desaturase 1 deletion drives susceptibility to NAFLD and hepatocarcinoma. Hepatology Communications, 2022;00:1-13.
Lobasso S, Lobaccaro JMA, Angelini R. Editorial: The multifaceted roles of lipids in physiological and pathophysiological states. Front Physiol. 2022 13:930962. https://doi.org/10.3389/fphys.2022.930962